Estra Tablets (Sertraline as HCl) by Life Pharmaceutical Company

Drug Category: Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)

Indication:  For the management of major depressive disorder, posttraumatic stress disorder, obsessive-compulsive disorder, panic disorder with or without agoraphobia, premenstrual dysphoric disorder, social phobia, premature ejaculation, and vascular headaches.

Composition:

Each Tablet contains:

• Sertraline as HCl………………………………….50mg

Pharmacological Action:

• Sertraline: The exact mechanism of action sertraline is not fully known, but the drug appears to selectively inhibit the reuptake of serotonin at the presynaptic membrane. This results in an increased synaptic concentration of serotonin in the CNS, which leads to numerous functional changes associated with enhanced serotonergic neurotransmission. It is suggested that these modifications are responsible for the antidepressant action observed during long term administration of antidepressants. It has also been hypothesized that obsessive-compulsive disorder is caused by the dysregulation of serotonin, as it is treated by sertraline, and the drug corrects this imbalance.

Presentation:

• Tablets