Eryc Gel (Isotretinoin & Erythromycine) by Life Pharmaceutical Company

Drug Category: Anti-acne Agents/ Anti-Bacterial Agents

Indication: For the treatment of Acne vulgaris, Alternative to penicillin in hypersensitive patients, Bacterial infections, Bone and joint infection, Breast cancer, Bronchitis, Endocarditis, Erythrasma, Eye infections, GI infections, Gonorrhoea, Heart failure, Lower respiratory tract infections, Lymphogranuloma venereum, Ophthalmia neonatorum, Otitis media, Pharyngitis, Pneumonia, Prophylaxis of bacterial endocarditis, Rosacea, Sexually transmitted infections, Sinusitis, Skin infections, Soft tissue infections, Supraventricular arrhythmias (particularly atrial fibrillation), Surgical prophylaxis, Syphilis, Upper respiratory tract infections, and can also be given in adjunctive therapy as an alternative drug of choice in Diphtheria, Early lyme disease.

Composition:

Each gram contains:

• Isotretinoin………………………0.05%
• Erythromycine………………………2%

Pharmacological Action:

• Isotretinoin: Isotretinoin noticeably reduces the production of sebum and shrinks the sebaceous glands. It stabilises keratinization and prevents comedones from forming. It also reduces inflammation in moderate-severe inflammatory acne. The exact mechanism of action is unknown; however it is known that it alters DNA transcription.
• Erythromycin: Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

Presentation:

• Gel

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