Exenta Gel (Ketoconazole) by Life Pharmaceutical Company

Drug Category: Antifungal: Imodazole

Indication: Ketoconazole is primarily indicated in conditions like Candidal chronic paronychia, Chronic vaginal candidosis, Cutaneous candidiasis, Fungal prophylaxis, Liver transplant, Pityriasis capitis, Pityriasis versicolor, Recalcitrant cutaneous dermatophyte infection, Renal transplant, Seborrheic dermatitis, Serious chronic resistant mucocutaneous candidiasis, Serious git mycoses, Severe chronic mucocutaneous candidiasis, Social anxiety disorder, Systemic mycoses, Ventricular arrhythmias; Paroxysmal supraventricular tachyarrhythmias, and can also be given in adjunctive therapy as an alternative drug of choice in Prophylaxis of organ rejection in kidney allograft recipients.


Each gram contains:

  • Ketoconazole………………………….2%

Pharmacological Action:

  • Ketoconazole: Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.


  • Gel

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