Fusicare-B Cream (Fusidic acid & Betamethasone as Valerate) By Life Pharmaceutical Company
Drug Category: Anti-Bacterial Agents/ Anti-inflammatory Agents, Steroidal
Indication: For the treatment of bacterial infections.
Each gram contains:
- Fusidic acid…………………………2%
- Betamethasone as Valerate………0.1%
- Fusidic acid: Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
- Betamethasone: Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.