Bebate Ointment (Betamethasone dipropionate) by Life Pharmaceutical Company
Drug Category: Glucocorticoids/ Anti-inflammatory Agents, Steroidal
Indication: For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Each gram contains:
- Betamethasone Dipropionate………………………0.05%
- Ketoconazole: Betamethasone: Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.