Gleam Tablets (Glimepiride) by Life Pharmaceutical Company
Drug Category: Sulphonylurea/ Antidiabetics
Indication: Glimepiride is primarily indicated in conditions like NIDDM, Softening and dilatation of cervix before mechanical cervical dilatation.
Each Tablet contains:
- Glimepiride………………………2mg/ 4mg
- Glimepiride: The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.