Clomet Cream (Betamethasone dipropionate & Clotrimazole) By Life Pharmaceutical Company
Drug Category: Anti-inflammatory Agents, Steroidal/ Antifungal Agents
Indication: Betamethasone dipropionate & Clotrimazole is an antifungal and corticosteroid combination used to treat skin infections. It also relieves redness and itching associated with infections.
Each gram contains:
- Betamethasone dipropionate ……..…0.05%
- Clotrimazole…………………………….……. 1%
- Betamethasone: Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
- Clotrimazole: Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.