Albonix Suspension (Mebendazole) by Life Pharmaceutical Company

Drug Category: Antinematodal Agents/ Tubulin Modulators

Indication: For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Composition:

Each 5ml contains:

• Mebendazole…………………………………………….100mg

Pharmacological Action:

• Mebendazole: Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Presentation:

• Amber Glass Bottle
• Syrup in High Density Polyethylene Bottle

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