Lifzine Syrup (Cyclizine as HCl) by Life Pharmaceutical Company

Drug Category: Antiemetics/ Piperazine Derivatives

Indication: For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).

Composition:

Each 5ml contains:

• Cyclizine (as HCl)……………………..12.5mg

Pharmacological Action:

• Cyclizine: Vomiting (emesis) is essentially a protective mechanism for removing irritant or otherwise harmful substances from the upper GI tract. Emesis or vomiting is controlled by the vomiting centre in the medulla region of the brain, an important part of which is the chemotrigger zone (CTZ). The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing synapses. These types of neurons are especially involved in transmission from the vestibular apparatus to the vomiting centre. Motion sickness principally involves overstimulation of these pathways due to various sensory stimuli. Hence the action of cyclizine which acts to block the histamine receptors in the vomiting centre and thus reduce activity along these pathways. Furthermore since cyclizine possesses anti-cholinergic properties as well, the muscarinic receptors are similarly blocked.

Presentation:

• Amber Glass Bottle
• Syrup in High Density Polyethylene Bottle

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