Lifzol Paed.Suspension (Trimethoprim & Sulphamethoxazole) by Life Pharmaceutical Company

Drug Category: Folic acid inhibitor/Sulphonamide

Indication: Infection of respiratory, gastrointestinal tract, and skin infection. It is also effective in urinary tract infection.

Composition:

Each 5ml contains:

• Trimethoprim…………………………………40mg
• Sulphamethoxazole……………………….200mg

Pharmacological Action:

Trimethoprim: The active form of folate is tetra hydro-derivative that is formed through reduction by dihydrofolate reductase. This enzymatic reaction is inhibited by Trimethoprim, leading to a decrease in the folate coenzymes for purine, pyrimidine and amino acid synthesis. Bacterial reductase has much stronger affinity for Trimethoprim than does the mammalian enzyme.

Sulphamethoxazole: Being impermeable to folic acid, many bacteria must rely on their ability to synthesize folate from PABA, pteridine and glutamate. In contrast, human being cannot synthesize folic acid and must obtain preformed folate as a vitamin in their diet. Because of their structural similarity to PABA, the sulfonamides compete with this substrate for the enzyme dihydrofolate synthetase, thus preventing the synthesis of bacterial folic acid and formation of its one- carbon carrying cofactor. This deprives the cell of essential cofactor for purine, pyrimidine and amino acid synthesis.

Presentation:

• Amber Glass Bottle
• Syrup in High Density Polyethylene Bottle

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